Pair Name	Cordycepin, Temozolomide
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Inhibition-->Cell metastasis
Gene Regulation	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDH2	hsa1000
	Down-regulation	Expression	ZEB1	hsa6935
	Down-regulation	Expression	TWIST1	hsa7291
	Down-regulation	Expression	MYC	hsa4609
	Down-regulation	Expression	NFKB1	hsa4790
	Down-regulation	Expression	MCL1	hsa4170
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	CTNNB1	hsa1499
	Up-regulation	Expression	PDCD4	hsa27250
In Vitro Model	LN-229	Glioblastoma	Homo sapiens (Human)	CVCL_0393
Result	Cordycepin combined with temozolomide may down-regulate MYC through "MicroRNA in cancer, Proteoglycans in cancer, Pathways in cancer and PI3K-AKT signaling pathway", which in turn regulate the expression of MCL1, CTNNB1, MMP9, PDCD4, thus regulating cell proliferation, migration and apoptosis in glioblastoma.